Dyclonine


170



General information:


Withdrawn ID: 170
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N01BX02
R02AD04
Molecular Formula: C18H27NO2
Molweight: 289.413



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 1932



Side-effects:

Total reported cases (submitted by medical professionals) with Dyclonine as primary suspect: 39


Reported final outcomes:
Hospitalization (initial or prolonged): 15
Death: 10
Life-Threatening condition: 4
Intervention required to prevent permanent impairment/damage: 0


Reported side-effects:

Side-effect Case number
Toxicity to various agents18
SOFT TISSUE NECROSIS9
Metabolic acidosis7
Confusional state6
Respiratory alkalosis5
Mental status changes4
Drug ineffective4
Completed suicide4
Tenderness3
Pain in extremity3
Pain3
Hypersensitivity3
Cardiac arrest3
Urine ketone body present2
Tinnitus2
THERMAL BURN2
Tachypnoea2
TACHYCARDIA2
Skin plaque2
Pulmonary oedema2
Peripheral swelling2
Paraesthesia2
Papule2
ORAL PAIN2
OESOPHAGEAL STENOSIS2
Oedema peripheral2
Musculoskeletal stiffness2
Mobility decreased2
Hyperkeratosis2
Condition aggravated2
Cognitive disorder2
Coagulopathy2
Blister2
Wrong schedule1
VOMITING1
VISION BLURRED1
Systemic inflammatory response syndrome1
Squamous cell carcinoma1
Skin irritation1
Skin hypertrophy1
Skin hyperpigmentation1
Seizure1
Secretion discharge1
RETCHING1
Respiratory rate increased1
Respiratory arrest1
Renal injury1
Rash maculo-papular1
Rash1
Pupils unequal1
Pulmonary hypertension1
Product dispensing error1
Product contamination chemical1
Product administration error1
Poisoning1
Peritoneal haemorrhage1
Parakeratosis1
Overdose1
OROPHARYNGEAL PAIN1
Oliguria1
OESOPHAGEAL ULCER1
Neurological decompensation1
Nervous system disorder1
Necrolytic acral erythema1
Local swelling1
Liver injury1
Liver function test abnormal1
Ketonuria1
Jaundice1
Intestinal ischaemia1
Immobile1
Hypotension1
Hypoaesthesia1
Hypertension1
Hyperglycaemia1
Hyperdynamic left ventricle1
Hepatitis C1
Hepatitis1
Heart rate increased1
Headache1
Haemorrhage1
Haemoglobin decreased1
Haemodynamic instability1
Haemobilia1
Gallbladder rupture1
Extravasation1
Erythema1
Epidermal necrosis1
Eosinophil count1
Dyspnoea1
DYSPHAGIA1
Drug-induced liver injury1
Drug hypersensitivity1
DIZZINESS1
Diplopia1
Dilatation atrial1
DIET REFUSAL1
Dermatitis psoriasiform1
Death1
CRYING1
Chronic papillomatous dermatitis1
Cholecystitis chronic1
Cholecystitis1
CHEST DISCOMFORT1
Cerebrovascular accident1
Cellulitis1
Cardio-respiratory arrest1
Body temperature decreased1
Blood pressure decreased1
Blood creatinine increased1
Asthenia1
Application site vesicles1
Application site reaction1
Application site hypersensitivity1
Anion gap increased1
Analgesic drug level increased1
Agitation1
Acute abdomen1
Acetonaemia1
Accidental exposure to product1
ACCIDENTAL EXPOSURE1
ACCIDENTAL DRUG INTAKE BY CHILD1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P00352 223.9 Retinal dehydrogenase 1 AL1A1_HUMAN
P02545 631 Prelamin-A/C LMNA_HUMAN
P22303 181 Acetylcholinesterase ACES_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: N/A
LD50: 440 mg/kg



External links:

ChEBML: CHEMBL1201217
DrugBank: DB00645